Stem Cell Research Laboratory (SCRL)

Introduction
Stem Cell Research Laboratory (SCRL) offers research facilities focused on stem cell culture, DNA and RNA analysis and gene expression.

Lab Equipment :

Equipment_SCRL

 

Staffs:
Prof. Dr. Noor Hayaty Abu Kasim (Lab coordinator)
Junaida @ Maimunah Hassan Basari (Science Officer)

Contact:
Tel : 03-7967 7492/ 6461
Email: junaida@um.edu.my

Address:
Stem Cell Research Laboratory,
Level 3, Block D,
Faculty of Dentistry, University of Malaya,
50603, Kuala Lumpur.

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Lecture Series: Everything U Always Wanted to Know..(Part 2)

Dental Research Management Centre (DRMC), Faculty of Dentistry with HIR/MoHE/Dent/11
Invites you to:
LS_Alex2_09022015

ABSTRACTS

Everything You Always Wanted to Know About Shrinkage Stress But Were Afraid to Ask
Part 2 – A Simple Predictive Formula for Laboratory Shrinkage Stress Measurement

The shrinkage stress that a resin composite can generate is usually assessed using disc specimens attached to a uniaxial tensile-test or cantilever beam-bending equipment. It is generally recognized that shrinkage stress depends on the composite’s final elastic modulus, total shrinkage strain, dimensions of the specimen and stiffness of the stress-measuring equipment. However, the exact relationship is not known and there have been many contradictory results reported in the literature, notably, the shrinkage stress reducing with an increasing C-factor. Using a Maxwell-type viscoelastic model, a simple predictive formula for the laboratory-measured shrinkage stress has been derived. Comparisons of its predictions with results reported in the literature confirm the general applicability of this formula. These include the effect of machine stiffness on the relationships among shrinkage stress, material properties and specimen dimensions, the possible reduction in shrinkage stress with an increasing C-factor, and the effect of filler volume on shrinkage stress. The new shrinkage stress formula can therefore help resolve most, if not all, of the apparent contradictions in the reported results. It can also provide useful material design pointers for reducing shrinkage stress.

Bio-Sketch –

Professor Dr. Alex Fok
BEng (Manchester), BA (UK), MSc (Oxford), Ph.D (Manchester)

Dr Fok obtained his BEng and PhD, both in Mechanical Engineering, from the University of Manchester, UK. He has expertise in structural and stress analysis, having spent 4 years working as a structural analyst in the nuclear industry after gaining his PhD. Prior to moving to Minnesota, he was Senior Lecturer in Mechanical Engineering at the University of Manchester.

Dr Fok’s research activities cover a range of topics in solid mechanics, nuclear graphite technology and biomechanics, both at a fundamental level and related to practical applications. These include statistical analysis of brittle failure, fractal finite elements, micro-structural modeling of materials, material characterization using full-field strain measurement and inverse methods, multiple fracture from dynamic stresses, buckling of thin embedded shells and the biomechanics of dental restorations. The finite element method forms the main tool of his research.

In 2007, Dr Fok accepted the invitation of the University of Minnesota School of Dentistry to become Director of the Minnesota Dental Research Center for Biomaterials and Biomechanics (MDRCBB). Established as an industry-academic collaboration with funding from the 3M Foundation and 3M Dental Products Division, the MDRCBB works closely with the industry on the development of new dental products and biomaterials.

Dr Fok’s current research activities include shape optimization of dental restorations, shrinkage strain measurement using digital image correlation, nondestructive examination of interfacial debonding using acoustic emission and development of alternative bond tests for dental materials. Together with colleagues from the Dental School, he has recently been awarded an NIH grant looking at the possible effect of bacterial activities on the degradation of composite restorations. He has also been successful in securing two grants from the DOE, one with colleagues from the Department of Civil Engineering, to continue his work on nuclear.

Awards

Awards for Faculty Members 2012

Malaysia Technology Expo, 2012 (MTE). The Leading International Invention and Innovation Expo, Putra World Trade Centre, Kuala Lumpur, 16-18 Februari 2012

Best Research Award/Gold Medal – Producing maxillofacial implants of titanium alloy through metal injection moulding using plam oil based binder system.

  • Prof. Madya Noor Hayaty Abu Kasim
  • Prof. Dr. Zainal Ariff Abdul Rahman

Awards for Faculty Members 2011

Research Institution/Educational Institution [Rekacipta & Inovasi](Perubatan) 22nd International, Innovation and Technology Exhibition (ITEX) 2011, Kuala Lumpur Convention Centre (KLCC), Kuala Lumpur, Malaysia (20-22 May 2011)

Gold Medal – New generation of dental post based on the concept of functionally graded

  • Prof. Madya Dr. Noor Hayaty Abu Kasim
  • Dr. Ahmed Abdullah Madfa

Silver Medal – Dental stem cells produce insulin:a breakthrouh in type 1 diabetes

  • Prof. Madya Dr. Noor Hayaty Abu Kasim
  • Prof. Madya Dr. Sabri Musa
  • Prof. Dr. Rosnah Mohd. Zain
  • Dr. Zeti Adura Che Abdul Aziz
  • Dr. Mariam AbdullahDr. Vijayendran Govindasamy

Bronze Medal – Mesenchymal stem cells from dental pulp:a new tool in liver dysfunction treatment |

  • Prof. Madya Dr. Noor Hayaty Abu Kasim
  • Prof. Madya Dr. Sabri Musa
  • Prof. Dr. Rosnah Mohd. Zain
  • Dr. Zeti Adura Che Abdul Aziz
  • Dr. Mariam AbdullahDr. Vijayendran Govindasamy

Malaysian Dental Association/FDI World Dental Federation Congress 68th MDA AGM & Trade Exhibition, 10-12 Jun 2011

1st Place “Poster Category” – Effect of disinfectant and impression trays on the dimensional stability of alginate impression |

  • Dr. Siti Fauzza Ahmad

3rd National Dental Students’ Scientific Conference 2011 (9 Mac 2011)

1st Prize: Poster Presentation – Comparison Audit of Orthognathic Surgeries between University of Malaya and University of Sheffield |

  • Dr. Wey Mang Chek

3rd Place: Poster Presentation – The survival of single-unit crowns made by the undergraduates of Dental Faculty of University Malaya

  • Dr. Norasmatul Akma Bte Ahmad

The Asia Pacific Dental Students Association (APDSA) APDSA 2011 Bangkok, Thailand, 17 Ogos 2011

3rd Place (Poster presentation) – Safety zone for mini-implant in maxilla |

  • Prof. Madya Dr. Ngeow Wei Cheong
  • Dr. Wey Mang Chek

Awards for Faculty Members 2011

Research Institution/Educational Institution [Rekacipta & Inovasi](Perubatan) 22nd International, Innovation and Technology Exhibition (ITEX) 2011, Kuala Lumpur Convention Centre (KLCC), Kuala Lumpur, Malaysia (20-22 May 2011)

Gold Medal – New generation of dental post based on the concept of functionally graded

  • Prof. Madya Dr. Noor Hayaty Abu Kasim
  • Dr. Ahmed Abdullah Madfa

Silver Medal – Dental stem cells produce insulin:a breakthrouh in type 1 diabetes

  • Prof. Madya Dr. Noor Hayaty Abu Kasim
  • Prof. Madya Dr. Sabri Musa
  • Prof. Dr. Rosnah Mohd. Zain
  • Dr. Zeti Adura Che Abdul Aziz
  • Dr. Mariam AbdullahDr. Vijayendran Govindasamy

Bronze Medal – Mesenchymal stem cells from dental pulp:a new tool in liver dysfunction treatment |

  • Prof. Madya Dr. Noor Hayaty Abu Kasim
  • Prof. Madya Dr. Sabri Musa
  • Prof. Dr. Rosnah Mohd. Zain
  • Dr. Zeti Adura Che Abdul Aziz
  • Dr. Mariam AbdullahDr. Vijayendran Govindasamy

Malaysian Dental Association/FDI World Dental Federation Congress 68th MDA AGM & Trade Exhibition, 10-12 Jun 2011

1st Place “Poster Category” – Effect of disinfectant and impression trays on the dimensional stability of alginate impression |

  • Dr. Siti Fauzza Ahmad

3rd National Dental Students’ Scientific Conference 2011 (9 Mac 2011)

1st Prize: Poster Presentation – Comparison Audit of Orthognathic Surgeries between University of Malaya and University of Sheffield |

  • Dr. Wey Mang Chek

3rd Place: Poster Presentation – The survival of single-unit crowns made by the undergraduates of Dental Faculty of University Malaya

  • Dr. Norasmatul Akma Bte Ahmad

The Asia Pacific Dental Students Association (APDSA) APDSA 2011 Bangkok, Thailand, 17 Ogos 2011

3rd Place (Poster presentation) – Safety zone for mini-implant in maxilla |

  • Prof. Madya Dr. Ngeow Wei Cheong
  • Dr. Wey Mang Chek

Awards for Faculty Members 2010

Rekacipta dan Inovasi (Perubatan) Malaysia Technology Expo 2010 (4-6 Februari 2010)

Gold Medal -The design, development and fabrication of custom made reconstruction and implants for medical application |

  • Prof. Dr. Zainal Ariff Abdul Rahman

Ekspo Penyelidikan,Rekacipta & Inovasi UM 2010 UMEXPO (1-3 April 2010)

Gold Medal for Student Research Best of Category-Science/Medicine/Dentistry -Processed Dentine as bone graft substitute innovation. | Dr. Ha Kien Oon

Gold Medal for Medicine & Allied Health Sciences – Image cytometry in determining the ploidy status of the tissues |

  • Prof. Madya Dr. P. Shanmusuntharam
  • Prof. Dr. Rosnah Mohd. Zain

Gold Medal for Medicine & Allied Health Sciences – Development of the Novel Dental Post with The Functionally Graded Design to Restore Endodontically Treated Teeth. | Prof. Madya Dr. Noor Hayaty Binti Abu Kasim

Silver Medal for Medicine & Allied Health Sciences -Isolation, Characterization and Multiliniage Differentiation of Post Natal Stem Cells from Dental Pulp. |

  • Dr. Zeti Adura Abdul Aziz
  • Prof. Madya Dr. Sabri Musa
  • Prof. Madya Dr. Noor Hayaty Abu Kasim
  • Prof. Dr. Rosnah Mohd. Zain

Rekacipta dan Inovasi (Perubatan) 21st International, Innovation and Technology Exhibition, ITEX 2010 Kuala Lumpur, Malaysia, 14th -16th May 2010

Gold Medal for Rekacipta dan Inovasi (Perubatan) – Revolutionary Endodontic Radiographic Holder-(K-Endo) |

  • Dr. Kathiravan Purmal
  • Prof. Dr. Phrabhakaran Nambiar
  • Dr. Norliza Ibrahim

Gold Medal for Biotechnology, Health & Fitness – New generation of dental posts for rehabilitation of endodontically treated tooth | Prof. Madya Dr. Noor Hayaty Abu Kasim

Gold Medal for Biotechnology, Health & Fitness – Microcapsules for self-healing dental material | Prof. Madya Dr. Noor Hayaty Abu Kasim

7th Biennial Conference PDAA Manila, Philippine, 7th-8th July 2010

Gold Medal for The Best Poster – Intracanal placement of calcium hydroxide in teeth with simulated immature apices. | Prof. Dr. Nik Noriah Nik Hussein

BioInno Award (1-3 November 2010)

Gold Medal for Woman Bio Innovator of the Year -New generation of the dental posts for endodontic application. |

Prof. Madya Dr. Noor Hayaty Abu Kasim

Gold Medal for Medical Research Field -New generation of the dental posts for endodontic application. |

  • Prof. Madya Dr. Noor Hayaty Abu Kasim
  • Dr. Ahmed Abdullah Madfa

Malaysia Technology Expo 2010(4-6 Februari 2010)

Silver Medal for Rekacipta dan Inovasi (Perubatan) -A Novel Device to Restore Masticatory Function | Prof. Madya Dr. Noor Hayaty Abu Kasim

Bronze Medal for Rekacipta dan Inovasi (Perubatan) -Liquid Nitrogen Treated Autologous Dentine as Bone Substitute |

  • Dr. Ha Kien Oon
  • Prof. Dr. Palasuntharam Shanmuhasuntharam
  • Prof. Dr. Siar Chong Huat

3rd International Conference on Functional Materials and Devices (ICFMD), Kuala Terengganu, Malaysia, 14th -17th June 2010

Silver Medal for the Best Poster – A New Multilayer Composite with Functionally Graded Design for Endodontic Application. | Prof. Madya Dr. Noor Hayaty Abu Kasim

21st International, Innovation and Technology Exhibition, ITEX 200, Kuala Lumpur, Malaysia, 14th -16th May 2010

Silver Medal for Biotechnology, Health & Fitness – Tooth and diabetes connection: extracted tooth and control of hyperglycemia.

  • Prof. Madya Dr. Sabri Musa-Ketua Projek
  • Prof. Madya Dr. Noor Hayaty Abu Kasim
  • Prof. Dr. Rosnah Mohd. Zain
  • Dr. Zeti Adura Che Ab Aziz

Silver Medal for Biotechnology, Health & Fitness – Processed dentine as a bone graft substitute innovation

  • Dr. Ha Kien Oon
  • Prof. Dr. Siar Cohng Huat
  • Prof. Madya Dr. P. Shanmuhasunthaam

1st Malaysian Oncology Society (MOS) and Egyptian Oncology Society (EOS) Conference (1-2 Mei 2010)

1st Prize – Genetic polymorphisms and risk of oral cancer

  • Dr. Siti Mazlipah Ismail
  • Prof. Dr. Rosnah Mohd. Zain

67th MDA/FDI International Scientific Convention & Trade Exhibition, KLCC, 10-13 Jun 2010

1st Prize Oral Presentation -How many 28 or 32 teeth? Where do we Malaysians stand?

  • Dr. Jacob John
  • Dr. Nor Himazian Mohamed
  • Prof. Dr. Phrabhakaran Nambiar

2nd Prize Poster Presentation -Prevalence of oral mucosal lesions and related risk habits in outpatients of two dental clinics in Malaysia and Yemen

  • Prof. Dr. Rosnah Mohd. Zain
  • Dr. Nor Himazian Mohamed

35th Annual Conference of the Malaysian Society for Biochemistry & Molecular Biology, Equatorial Hotel, Bangi, 27th-28th July 2010

The Best Poster – Molecular cytogenetic of oral squamous cell carcinoma

  • Prof. Dr. Zainal Ariff Abdul Rahman
  • Prof. Dr. Rosnah Mohd Zain
  • Dr. Siti Mazlipah Ismail
  • Dr. Zuraiza Mohamad Zaini

The Best Poster – Expression of GNA12 and IFITM3 and their roles in oral cancer

  • Prof. Dr. Rosnah Mohd Zain
  • Prof. Dr. Zainal Ariff Abdul Rahman

Awards for Individual 2010

Fellow of the Academy of Sciences Malaysia (ASM), 2010 awarded to Prof. Dr. Rosnah Mohd. Zain at the ASM Lecture Series (13 November 2010) Advancing science through the concept of sharing-the mouth cancer scenario

Woman Bio Innovator of the Year awarded to Prof. Madya Dr. Noor Hayaty Abu Kasim at BioInno 2010 for New generation of the dental posts for endodontic application.

Young Researchers Award awarded to

  • Dr. Aezy Noorazah Omar
  • Prof. Dr. Siar Chong Huat
  • Prof. Dr. Ong Siew Tin

at the 9th Asian Congress on Oral and Maxillofacial Surgery 2010

ReDReG

Oral Cancer Research & Coordinating Centre (OCRCC)

Research centre vision:
To be an internationally renowned research centre in oral cancer through data and tissue sharing for research such that there is successful translation of basic research into clinical practice leading to excellence in innovation, publication and teaching

Research centre mission:
To advance knowledge and learning in oral cancer through quality research and education for the nation and for humanity

Research centre objectives:
To reduce impact of oral cancer on the Malaysian population via:

  • the maintenance and enhancement of the system of collection and storage of data and specimens through the Malaysian Oral Cancer Database & Tissue Bank System (MOCDTBS) to facilitate future research efforts
  • coordination of research activities on oral cancer in Malaysia to avoid research overlaps
  • creation of a conducive environment through the sharing of available, limited resources from the database and optimizing the use of specimens from the tissue bank to achieve excellence, creativity and innovation in research
  • conducting training in clinical expertise
  • establishing networking with institutions locally and internationally to further accelerate research in oral cancer
  • disseminating information and creating awareness to the Malaysian public on the disease
  • being a resource centre for research, consultancy and laboratory techniques in this field
  • being a resource centre for postgraduate training through the availability of clinical expertise and resources (data/specimens)


Summary and principal aims

Oral cancer is one form of malignancy that is very easily detected through an oral examination. While it is not among the top 10 cancers, it is prevalent especially among ethnic Indians where the incidence ranked within the top ten cancers in Malaysia. Most oral cancer patients present at very late stages making ideal management impossible and thus leading to 5 years survival of less than 50% with those surviving having a poor quality of life. With the current limited knowledge on oral cancer and its risk factors, intervention programs are only limited to those with supposedly high risks. However, there are other factors, which has been associated with oral cancer such as the physical environment, genetic make-up and lifestyle that need to be further studied so that the information derived can equip health professionals to effectively and efficiently manage equitable intervention program aimed at reducing the incidence of oral cancer.

Therefore, OCRCC was established with the aim to carry out research in oral cancer and to coordinate oral cancer research in Malaysia. The oral cancer research includes various aspects such as risk factors, gene expression, treatment outcome, survival as well as impact of the disease to the patient’s quality of life in our effort to understand the underlying mechanisms of this disease. Subsequently, the development and maintenance of an oral cancer database and tissue bank allows for follow-up of these patients to evaluate the treatment effect outcome so that suitability of the treatment strategies employed can be assessed and more meaningful molecular epidemiology research to be carried out such that there is successful translation of basic research into clinical practice.

OCRCC is made up of experts from various disciplines, including oral maxillofacial surgeons, ENTs, pathologists, epidemiologists and scientists. Therefore, we were able to undertake a wide range of not just research activities, but also organization of seminars and increasing oral cancer awareness activities.

Key achievements
OCRCC has successfully developed a biobanking system called the Malaysian Oral Cancer Database and Tissue Bank System (MOCDTBS) where this system is designed to collect, process and stores data and biological specimens to serve current and future research in oral cancer. Data and specimens collected from this system, together with successful collaboration with other academic, government and non-governmental institutions has opened the path for various research in the area of genomics, transcriptomics, proteomics, cytogenetics, epidemiology, nutrition and quality of life. Furthermore, this successful collaboration effort has translated into the establishment and characterization of oral cancer cell lines which is an important achievement to further expand on oral cancer research activities.
To date, 24 research papers has been published since year 2005 and one patent was filed by one of our research collaborators. Additionally, postgrad students utilising data and/or specimens and expertise from this centre have also won several national and international awards for their research including:

  • UICC International Cancer Technology Transfer Fellowship by International Union Against Cancer (UICC), Oral & Pharyngeal Cancer Branch (NIH), Bethesda, US for research project entitled ‘Establishment of mouse models to understand oral cancer development’
  • 1st prize for abstract entitled ’Genetic polymorphism and risk of oral cancer’ presented at 1st Malaysian Oncology Society-Egyptian Oncology Society 2010
  • Gold medal at the University of Malaya Research and Innovation Expo 2010 for abstract entitled ‘Image Cytometry in determining the ploidy status of the tissue’
  • Travel Award to Japan 2009 for a paper titled Single Nucleotide Polymorphisms (SNPs) Discovery in Oral Squamous Cell Carcinoma (OSCC)
  • Best paper award at the International Academy of Dental Research (IADR) 2008 for abstract entitled ‘Expression of Ki-67 and MMP-1 in Oral Squamous Cell Carcinoma (OSCC), Oral Lichen Planus (OLP) and Fibroepithelial Hyperplasia (FEH)’.

Research Centre Director:

Prof. Dr. Rosnah Binti Mohd Zain

Contact details

For further information, please contact us at:
Oral Cancer Research &
Coordinating Centre (OCRCC)
Faculty of Dentistry, University of Malaya
Tel: 03-79674896
Fax: 03-79547301
Handphone: 016-2765720
Email:
oralcancer2003@um.edu.my
Website: http://mouthcancermalaysia.um.edu.my/